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Zinc-mediated Allosteric Inhibition of Caspase-6

Zinc and caspase-6 have independently been implicated in several neurodegenerative disorders. Depletion of zinc intracellularly leads to apoptosis by an unknown mechanism. Zinc inhibits cysteine proteases, including the apoptotic caspases, leading to the hypothesis that zinc-mediated inhibition of c...

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Autors principals: Velázquez-Delgado, Elih M., Hardy, Jeanne A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476268/
https://ncbi.nlm.nih.gov/pubmed/22891250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.397752
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