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Zinc-mediated Allosteric Inhibition of Caspase-6
Zinc and caspase-6 have independently been implicated in several neurodegenerative disorders. Depletion of zinc intracellularly leads to apoptosis by an unknown mechanism. Zinc inhibits cysteine proteases, including the apoptotic caspases, leading to the hypothesis that zinc-mediated inhibition of c...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3476268/ https://ncbi.nlm.nih.gov/pubmed/22891250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.397752 |
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