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Substrate-induced conformational changes occur in all cleaved forms of caspase-6
Caspase-6 is an apoptotic cysteine protease that also governs disease progression in Huntington’s and Alzheimer’s Diseases. Caspase-6 is of great interest as a target for treatment of these neurodegenerative diseases, however the molecular basis of caspase-6 function and regulation remains poorly un...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3030624/ https://ncbi.nlm.nih.gov/pubmed/21111746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.11.031 |
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