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Caspase-6 latent state stability relies on helical propensity

Caspase-6 is an apoptotic protease that also plays important roles in neurodegenerative disorders including Huntington’s and Alzheimer’s diseases. Caspase-6 is the only caspase known to form a latent state in which two extended helices block access to the active site. These helices must convert to s...

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Bibliografiske detaljer
Main Authors: Vaidya, Sravanti, Hardy, Jeanne A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086340/
https://ncbi.nlm.nih.gov/pubmed/21381717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2001664
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