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Caspase-6 latent state stability relies on helical propensity
Caspase-6 is an apoptotic protease that also plays important roles in neurodegenerative disorders including Huntington’s and Alzheimer’s diseases. Caspase-6 is the only caspase known to form a latent state in which two extended helices block access to the active site. These helices must convert to s...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086340/ https://ncbi.nlm.nih.gov/pubmed/21381717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2001664 |
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