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Discovery of an allosteric site in the caspases

Allosteric regulation of proteins by conformational change is a primary means of biological control. Traditionally it has been difficult to identify and characterize novel allosteric sites and ligands that freeze these conformational states. We present a site-directed approach using Tethering for tr...

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Detalhes bibliográficos
Main Authors: Hardy, Jeanne A., Lam, Joni, Nguyen, Jack T., O'Brien, Tom, Wells, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC514654/
https://ncbi.nlm.nih.gov/pubmed/15314233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404781101
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