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Discovery of an allosteric site in the caspases
Allosteric regulation of proteins by conformational change is a primary means of biological control. Traditionally it has been difficult to identify and characterize novel allosteric sites and ligands that freeze these conformational states. We present a site-directed approach using Tethering for tr...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514654/ https://ncbi.nlm.nih.gov/pubmed/15314233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404781101 |
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