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A common allosteric site and mechanism in caspases
We present a common allosteric mechanism for control of inflammatory and apoptotic caspases. Highly specific thiol-containing inhibitors of the human inflammatory caspase-1 were identified by using disulfide trapping, a method for site-directed small-molecule discovery. These compounds became trappe...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2006
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1458511/ https://ncbi.nlm.nih.gov/pubmed/16682620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602571103 |
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