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Turning a protein kinase on or off from a single allosteric site via disulfide trapping
There is significant interest in identifying and characterizing allosteric sites in enzymes such as protein kinases both for understanding allosteric mechanisms as well as for drug discovery. Here, we apply a site-directed technology, disulfide trapping, to interrogate structurally and functionally...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076885/ https://ncbi.nlm.nih.gov/pubmed/21430264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102376108 |
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