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Quantifying Correlations Between Allosteric Sites in Thermodynamic Ensembles

Allostery describes altered protein function at one site due to a perturbation at another site. One mechanism of allostery involves correlated motions, which can occur even in the absence of substantial conformational change. We present a novel method, “MutInf”, to identify statistically significant...

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Bibliographic Details
Main Authors: McClendon, Christopher L., Friedland, Gregory, Mobley, David L., Amirkhani, Homeira, Jacobson, Matthew P.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790287/
https://ncbi.nlm.nih.gov/pubmed/20161451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct9001812
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