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Turning a protein kinase on or off from a single allosteric site via disulfide trapping
There is significant interest in identifying and characterizing allosteric sites in enzymes such as protein kinases both for understanding allosteric mechanisms as well as for drug discovery. Here, we apply a site-directed technology, disulfide trapping, to interrogate structurally and functionally...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076885/ https://ncbi.nlm.nih.gov/pubmed/21430264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102376108 |
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