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Self-Assembling Small Molecules Form Nanofibrils That Bind Procaspase-3 to Promote Activation
Modulating enzyme function with small molecule activators, as opposed to inhibitors, offers new opportunities for drug discovery and allosteric regulation. Previously, we identified a compound, called 1541, from a high through-put screen (HTS) that stimulates activation of a proenzyme, procaspase-3,...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3253528/ https://ncbi.nlm.nih.gov/pubmed/22066605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja208350u |
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