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G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting
OBJECTIVE: G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycle determines the sensitivity of glucose-stimulated...
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| Veröffentlicht in: | Mol Metab |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7369601/ https://ncbi.nlm.nih.gov/pubmed/32569842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101043 |
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