Pancreatic Islet Beta Cell-Specific Deletion of G6pc2 Reduces Fasting Blood Glucose

The G6PC1, G6PC2 and G6PC3 genes encode distinct glucose-6-phosphatase catalytic subunit (G6PC) isoforms. In mice, germline deletion of G6pc2 lowers fasting blood glucose (FBG) without affecting fasting plasma insulin (FPI) while, in isolated islets, glucose-6-phosphatase activity and glucose cyclin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Mol Endocrinol
Prif Awduron: Bosma, Karin J., Rahim, Mohsin, Singh, Kritika, Goleva, Slavina B., Wall, Martha L., Xia, Jing, Syring, Kristen E., Oeser, James K., Poffenberger, Greg, McGuinness, Owen P., Means, Anna L., Powers, Alvin C., Li, Wen-hong, Davis, Lea K., Young, Jamey D., O’Brien, Richard M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7331801/
https://ncbi.nlm.nih.gov/pubmed/32213654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JME-20-0031
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