G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting

OBJECTIVE: G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycle determines the sensitivity of glucose-stimulated...

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Dades bibliogràfiques
Publicat a:Mol Metab
Autors principals: Bosma, Karin J., Rahim, Mohsin, Oeser, James K., McGuinness, Owen P., Young, Jamey D., O'Brien, Richard M.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Brief Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7369601/
https://ncbi.nlm.nih.gov/pubmed/32569842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101043
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