Loading...
Mdm2 mediated neddylation of pVHL blocks the induction of anti-angiogenic factors.
Mutations in the tumor suppressor TP53 are rare in renal cell carcinomas. p53 is a key factor for inducing anti-angiogenic genes and RCC are highly vascularized, which suggests that p53 is inactive in these tumors. One regulator of p53 is the Mdm2 oncogene, which is correlated with high-grade, metas...
Na minha lista:
| Udgivet i: | Oncogene |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7368819/ https://ncbi.nlm.nih.gov/pubmed/32555333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1359-4 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|