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Mdm2 mediated neddylation of pVHL blocks the induction of anti-angiogenic factors.
Mutations in the tumor suppressor TP53 are rare in renal cell carcinomas. p53 is a key factor for inducing anti-angiogenic genes and RCC are highly vascularized, which suggests that p53 is inactive in these tumors. One regulator of p53 is the Mdm2 oncogene, which is correlated with high-grade, metas...
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| Gepubliceerd in: | Oncogene |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7368819/ https://ncbi.nlm.nih.gov/pubmed/32555333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1359-4 |
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