OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance

Enhanced inflammation is believed to contribute to overnutrition-induced metabolic disturbance. Nutrient flux has also been shown to be essential for immune cell activation. Here, we report an unexpected role of nutrient-sensing O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in suppressing macr...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Yang, Yunfan, Li, Xiruo, Luan, Harding H., Zhang, Bichen, Zhang, Kaisi, Nam, Jin Hyun, Li, Zongyu, Fu, Minnie, Munk, Alexander, Zhang, Dongyan, Wang, Simeng, Liu, Yuyang, Albuquerque, João Paulo, Ong, Qunxiang, Li, Rui, Wang, Qi, Robert, Marie E., Perry, Rachel J., Chung, Dongjun, Shulman, Gerald I., Yang, Xiaoyong
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368321/
https://ncbi.nlm.nih.gov/pubmed/32601203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916121117
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