OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance

Enhanced inflammation is believed to contribute to overnutrition-induced metabolic disturbance. Nutrient flux has also been shown to be essential for immune cell activation. Here, we report an unexpected role of nutrient-sensing O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in suppressing macr...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Yang, Yunfan, Li, Xiruo, Luan, Harding H., Zhang, Bichen, Zhang, Kaisi, Nam, Jin Hyun, Li, Zongyu, Fu, Minnie, Munk, Alexander, Zhang, Dongyan, Wang, Simeng, Liu, Yuyang, Albuquerque, João Paulo, Ong, Qunxiang, Li, Rui, Wang, Qi, Robert, Marie E., Perry, Rachel J., Chung, Dongjun, Shulman, Gerald I., Yang, Xiaoyong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2020
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368321/
https://ncbi.nlm.nih.gov/pubmed/32601203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916121117
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