OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance

Enhanced inflammation is believed to contribute to overnutrition-induced metabolic disturbance. Nutrient flux has also been shown to be essential for immune cell activation. Here, we report an unexpected role of nutrient-sensing O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in suppressing macr...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Yang, Yunfan, Li, Xiruo, Luan, Harding H., Zhang, Bichen, Zhang, Kaisi, Nam, Jin Hyun, Li, Zongyu, Fu, Minnie, Munk, Alexander, Zhang, Dongyan, Wang, Simeng, Liu, Yuyang, Albuquerque, João Paulo, Ong, Qunxiang, Li, Rui, Wang, Qi, Robert, Marie E., Perry, Rachel J., Chung, Dongjun, Shulman, Gerald I., Yang, Xiaoyong
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368321/
https://ncbi.nlm.nih.gov/pubmed/32601203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916121117
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