OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance

Enhanced inflammation is believed to contribute to overnutrition-induced metabolic disturbance. Nutrient flux has also been shown to be essential for immune cell activation. Here, we report an unexpected role of nutrient-sensing O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in suppressing macr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yang, Yunfan, Li, Xiruo, Luan, Harding H., Zhang, Bichen, Zhang, Kaisi, Nam, Jin Hyun, Li, Zongyu, Fu, Minnie, Munk, Alexander, Zhang, Dongyan, Wang, Simeng, Liu, Yuyang, Albuquerque, João Paulo, Ong, Qunxiang, Li, Rui, Wang, Qi, Robert, Marie E., Perry, Rachel J., Chung, Dongjun, Shulman, Gerald I., Yang, Xiaoyong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368321/
https://ncbi.nlm.nih.gov/pubmed/32601203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916121117
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