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Mechanism of β-arrestin recruitment by the μ-opioid G protein-coupled receptor
Agonists to the μ-opioid G protein-coupled receptor (μOR) can alleviate pain through activation of G protein signaling, but they can also induce β-arrestin activation, leading to such side effects as respiratory depression. Biased ligands to μOR that induce G protein signaling without inducing β-arr...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7368253/ https://ncbi.nlm.nih.gov/pubmed/32601232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1918264117 |
| Oznake: |
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