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Mechanism of β-arrestin recruitment by the μ-opioid G protein-coupled receptor

Agonists to the μ-opioid G protein-coupled receptor (μOR) can alleviate pain through activation of G protein signaling, but they can also induce β-arrestin activation, leading to such side effects as respiratory depression. Biased ligands to μOR that induce G protein signaling without inducing β-arr...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Mafi, Amirhossein, Kim, Soo-Kyung, Goddard, William A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368253/
https://ncbi.nlm.nih.gov/pubmed/32601232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1918264117
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