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The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist
The kappa opioid receptor (κOR) is an important target for pain therapeutics to reduce depression and other harmful side effects of existing medications. The analgesic activity is mediated by κOR signaling through the adenylyl cyclase-inhibitory family of Gi protein. Here, we report the three-dimens...
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| I publikationen: | Proc Natl Acad Sci U S A |
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| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2020
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7084096/ https://ncbi.nlm.nih.gov/pubmed/32127473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910006117 |
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