Considerations and Caveats when Applying Global Sensitivity Analysis Methods to Physiologically Based Pharmacokinetic Models

Three global sensitivity analysis (GSA) methods (Morris, Sobol and extended Sobol) are applied to a minimal physiologically based PK (mPBPK) model using three model drugs given orally, namely quinidine, alprazolam, and midazolam. We investigated how correlations among input parameters affect the det...

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發表在:AAPS J
Main Authors: Liu, Dan, Li, Linzhong, Rostami-Hodjegan, Amin, Bois, Frederic Y., Jamei, Masoud
格式: Artigo
語言:Inglês
出版: Springer International Publishing 2020
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367914/
https://ncbi.nlm.nih.gov/pubmed/32681207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-020-00480-x
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