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3D genome organization contributes to genome instability at fragile sites

Common fragile sites (CFSs) are regions susceptible to replication stress and are hotspots for chromosomal instability in cancer. Several features were suggested to underlie CFS instability, however, these features are prevalent across the genome. Therefore, the molecular mechanisms underlying CFS i...

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Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Sarni, Dan, Sasaki, Takayo, Irony Tur-Sinai, Michal, Miron, Karin, Rivera-Mulia, Juan Carlos, Magnuson, Brian, Ljungman, Mats, Gilbert, David M., Kerem, Batsheva
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367836/
https://ncbi.nlm.nih.gov/pubmed/32680994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17448-2
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