A PIP(2) substitute mediates voltage sensor-pore coupling in KCNQ activation

KCNQ family K(+) channels (KCNQ1-5) in the heart, nerve, epithelium and ear require phosphatidylinositol 4,5-bisphosphate (PIP(2)) for voltage dependent activation. While membrane lipids are known to regulate voltage sensor domain (VSD) activation and pore opening in voltage dependent gating, PIP(2)...

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Vydáno v:Commun Biol
Hlavní autoři: Liu, Yongfeng, Xu, Xianjin, Gao, Junyuan, Naffaa, Moawiah M., Liang, Hongwu, Shi, Jingyi, Wang, Hong Zhan, Yang, Nien-Du, Hou, Panpan, Zhao, Wenshan, White, Kelli McFarland, Kong, Wenjuan, Dou, Alex, Cui, Amy, Zhang, Guohui, Cohen, Ira S., Zou, Xiaoqin, Cui, Jianmin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367283/
https://ncbi.nlm.nih.gov/pubmed/32678288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-1104-0
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