Activation and inhibition of nonsense-mediated mRNA decay control the abundance of alternative polyadenylation products

Alternative polyadenylation (APA) produces transcript 3′ untranslated regions (3′UTRs) with distinct sequences, lengths, stabilities and functions. We show here that APA products include a class of cryptic nonsense-mediated mRNA decay (NMD) substrates with extended 3′UTRs that gene- or transcript-le...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Kishor, Aparna, Fritz, Sarah E, Haque, Nazmul, Ge, Zhiyun, Tunc, Ilker, Yang, Wenjing, Zhu, Jun, Hogg, J Robert
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
RNA and RNA-protein complexes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367170/
https://ncbi.nlm.nih.gov/pubmed/32542372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa491
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