Alternative Polyadenylation and Nonsense-Mediated Decay Coordinately Regulate the Human HFE mRNA Levels

Nonsense-mediated decay (NMD) is an mRNA surveillance pathway that selectively recognizes and degrades defective mRNAs carrying premature translation-termination codons. However, several studies have shown that NMD also targets physiological transcripts that encode full-length proteins, modulating t...

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Bibliographic Details
Main Authors: Martins, Rute, Proença, Daniela, Silva, Bruno, Barbosa, Cristina, Silva, Ana Luísa, Faustino, Paula, Romão, Luísa
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329446/
https://ncbi.nlm.nih.gov/pubmed/22530027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035461
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