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The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs carrying premature translation termination codons. Generally, NMD is elicited if translation terminates >50–54 nucleotides (nt) upstream of an exon–exon junction. We have previously reported that human β-globin mRN...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1664719/ https://ncbi.nlm.nih.gov/pubmed/17077274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.201406 |
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