Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity

Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and selectively degrades mRNAs carrying premature termination codons (PTCs). The level of sensitivity of a PTC-containing mRNA to NMD is multifactorial. We have previously shown that human β-globin mRNAs carrying PTCs in cl...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Pereira, Francisco J.C., Teixeira, Alexandre, Kong, Jian, Barbosa, Cristina, Silva, Ana Luísa, Marques-Ramos, Ana, Liebhaber, Stephen A., Romão, Luísa
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513866/
https://ncbi.nlm.nih.gov/pubmed/26068473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv588
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