Activation and inhibition of nonsense-mediated mRNA decay control the abundance of alternative polyadenylation products

Alternative polyadenylation (APA) produces transcript 3′ untranslated regions (3′UTRs) with distinct sequences, lengths, stabilities and functions. We show here that APA products include a class of cryptic nonsense-mediated mRNA decay (NMD) substrates with extended 3′UTRs that gene- or transcript-le...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Kishor, Aparna, Fritz, Sarah E, Haque, Nazmul, Ge, Zhiyun, Tunc, Ilker, Yang, Wenjing, Zhu, Jun, Hogg, J Robert
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
Onderwerpen:
RNA and RNA-protein complexes
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367170/
https://ncbi.nlm.nih.gov/pubmed/32542372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa491
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