Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway

The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs containing long 3'UTRs to perform dual roles in mRNA quality control and gene expression regulation. However, expansion of vertebrate 3'UTR functions has required a physical expansion of 3'UTR lengths, complicating the proc...

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Foilsithe in:eLife
Main Authors: Ge, Zhiyun, Quek, Bao Lin, Beemon, Karen L, Hogg, J Robert
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2016
Ábhair:
Biochemistry
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764554/
https://ncbi.nlm.nih.gov/pubmed/26744779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11155
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