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Iron chelation inhibits mTORC1 signaling involving activation of AMPK and REDD1/Bnip3 pathways
The mammalian target of rapamycin (mTOR) functions as two complexes (mTORC1 and mTORC2), regulating cell growth and metabolism. Aberrant mTOR signaling occurs frequently in cancers, so mTOR has become an attractive target for cancer therapy. Iron chelators have emerged as promising anticancer agents...
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| Veröffentlicht in: | Oncogene |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7366895/ https://ncbi.nlm.nih.gov/pubmed/32541839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1366-5 |
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