Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells

Dihydroartemisinin (DHA), an anti-malarial drug, has been shown to possess potent anticancer activity, partly by inhibiting the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) signaling. However, how DHA inhibits mTORC1 is still unknown. Here, using rhabdomyosarcoma (RMS) as a model, we foun...

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發表在:Cells
Main Authors: Luo, Jun, Odaka, Yoshinobu, Huang, Zhu, Cheng, Bing, Liu, Wang, Li, Lin, Shang, Chaowei, Zhang, Chao, Wu, Yang, Luo, Yan, Yang, Shengyong, Houghton, Peter J., Guo, Xiaofeng, Huang, Shile
格式: Artigo
語言:Inglês
出版: MDPI 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8226784/
https://ncbi.nlm.nih.gov/pubmed/34205996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10061363
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