Substrate metabolism regulated by Sestrin2–mTORC1 alleviates pressure overload-induced cardiac hypertrophy in aged heart

Sestrin2 (Sesn2) is a stress sensor for the mammalian target of rapamycin complex 1 (mTORC1) pathway. Aging impairs cardiac mTORC1 activation, thereby sensitizing the heart to hypertrophy. C57BL/6 J young wild-type (young WT; 4–6 months), aged WT (24–26 months), and young Sestrin2 knockout mice (Y-S...

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Bibliographic Details
Published in:Redox Biol
Main Authors: Quan, Nanhu, Li, Xuan, Zhang, Jingwen, Han, Ying, Sun, Weiju, Ren, Di, Tong, Qian, Li, Ji
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363709/
https://ncbi.nlm.nih.gov/pubmed/32863202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101637
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