Activated protein C protects against pressure overload-induced hypertrophy through AMPK signaling

We found that the anticoagulant plasma protease, activated protein C (APC), stimulates the energy sensor kinase, AMPK, in the stressed heart by activating protease-activated receptor 1 (PAR1) on cardiomyocytes. Wild-type (WT) and AMPK-kinase dead (KD) transgenic mice were subjected to transverse aor...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Biochem Biophys Res Commun
Egile Nagusiak: Cates, Courtney, Rousselle, Thomas, Wang, Jinli, Quan, Nanhu, Wang, Lin, Chen, Xu, Yang, Likui, Rezaie, Alireza R, Li, Ji
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762421/
https://ncbi.nlm.nih.gov/pubmed/29287725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2017.12.125
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