Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of alcadein α–deficient mice

Alzheimer's disease (AD) is a very common neurodegenerative disorder, chiefly caused by increased production of neurotoxic β-amyloid (Aβ) peptide generated from proteolytic cleavage of β-amyloid protein precursor (APP). Except for familial AD arising from mutations in the APP and presenilin (PS...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Gotoh, Naoya, Saito, Yuhki, Hata, Saori, Saito, Haruka, Ojima, Daiki, Murayama, Chiaki, Shigeta, Mayo, Abe, Takaya, Konno, Daijiro, Matsuzaki, Fumio, Suzuki, Toshiharu, Yamamoto, Tohru
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363152/
https://ncbi.nlm.nih.gov/pubmed/32467230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012386
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