Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain

BACKGROUND: X11-family proteins, including X11, X11-like (X11L) and X11-like 2 (X11L2), bind to the cytoplasmic domain of amyloid β-protein precursor (APP) and regulate APP metabolism. Both X11 and X11L are expressed specifically in brain, while X11L2 is expressed ubiquitously. X11L is predominantly...

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Detalhes bibliográficos
Main Authors: Kondo, Maho, Shiono, Maki, Itoh, Genzo, Takei, Norio, Matsushima, Takahide, Maeda, Masahiro, Taru, Hidenori, Hata, Saori, Yamamoto, Tohru, Saito, Yuhki, Suzuki, Toshiharu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949864/
https://ncbi.nlm.nih.gov/pubmed/20843325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-35
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