Intracellular Trafficking of the Amyloid β-Protein Precursor (APP) Regulated by Novel Function of X11-Like

BACKGROUND: Amyloid β (Aβ), a causative peptide of Alzheimer's disease, is generated by intracellular metabolism of amyloid β-protein precursor (APP). In general, mature APP (mAPP, N- and O-glycosylated form) is subject to successive cleavages by α- or β-, and γ-secretases in the late protein s...

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Main Authors: Saito, Yuhki, Akiyama, Mayu, Araki, Yoichi, Sumioka, Akio, Shiono, Maki, Taru, Hidenori, Nakaya, Tadashi, Yamamoto, Tohru, Suzuki, Toshiharu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139598/
https://ncbi.nlm.nih.gov/pubmed/21818298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022108
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