X11 Proteins Regulate the Translocation of Amyloid β-Protein Precursor (APP) into Detergent-resistant Membrane and Suppress the Amyloidogenic Cleavage of APP by β-Site-cleaving Enzyme in Brain

X11 and X11-like proteins (X11L) are neuronal adaptor proteins whose association to the cytoplasmic domain of amyloid β-protein precursor (APP) suppresses the generation of amyloid β-protein (Aβ) implicated in Alzheimer disease pathogenesis. The amyloidogenic, but not amyloidolytic, metabolism of AP...

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Detalhes bibliográficos
Main Authors: Saito, Yuhki, Sano, Yoshitake, Vassar, Robert, Gandy, Sam, Nakaya, Tadashi, Yamamoto, Tohru, Suzuki, Toshiharu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602917/
https://ncbi.nlm.nih.gov/pubmed/18845544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801353200
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