X11 Proteins Regulate the Translocation of Amyloid β-Protein Precursor (APP) into Detergent-resistant Membrane and Suppress the Amyloidogenic Cleavage of APP by β-Site-cleaving Enzyme in Brain

X11 and X11-like proteins (X11L) are neuronal adaptor proteins whose association to the cytoplasmic domain of amyloid β-protein precursor (APP) suppresses the generation of amyloid β-protein (Aβ) implicated in Alzheimer disease pathogenesis. The amyloidogenic, but not amyloidolytic, metabolism of AP...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Saito, Yuhki, Sano, Yoshitake, Vassar, Robert, Gandy, Sam, Nakaya, Tadashi, Yamamoto, Tohru, Suzuki, Toshiharu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Protein Synthesis, Post-Translational Modification, and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602917/
https://ncbi.nlm.nih.gov/pubmed/18845544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801353200
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker