Physiological Mouse Brain Aβ Levels Are Not Related to the Phosphorylation State of Threonine-668 of Alzheimer's APP

BACKGROUND: Amyloid-β peptide species ending at positions 40 and 42 (Aβ40, Αβ42) are generated by the proteolytic processing of the Alzheimer's amyloid precursor protein (APP). Aβ peptides accumulate in the brain early in the course of Alzheimer's disease (AD), especially Aβ42. The cytopla...

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Detalhes bibliográficos
Main Authors: Sano, Yoshitake, Nakaya, Tadashi, Pedrini, Steve, Takeda, Shizu, Iijima-Ando, Kanae, Iijima, Koichi, Mathews, Paul M., Itohara, Shigeyoshi, Gandy, Sam, Suzuki, Toshiharu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2006
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762327/
https://ncbi.nlm.nih.gov/pubmed/17183681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000051
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