NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease

NGF has been implicated in forebrain neuroprotection from amyloidogenesis and Alzheimer's disease (AD). However, the underlying molecular mechanisms are still poorly understood. Here, we investigated the role of NGF signalling in the metabolism of amyloid precursor protein (APP) in forebrain ne...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Triaca, Viviana, Sposato, Valentina, Bolasco, Giulia, Ciotti, Maria Teresa, Pelicci, Piergiuseppe, Bruni, Amalia C., Cupidi, Chiara, Maletta, Raffaele, Feligioni, Marco, Nisticò, Robert, Canu, Nadia, Calissano, Pietro
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933663/
https://ncbi.nlm.nih.gov/pubmed/27076121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12473
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