Phosphorylation of Amyloid Precursor Protein (APP) at Thr668 Regulates the Nuclear Translocation of the APP Intracellular Domain and Induces Neurodegeneration

Amyloid precursor protein (APP) has eight potential phosphorylation sites in its cytoplasmic domain. Recently, it has demonstrated that the constitutive phosphorylation of APP at T668 (APP695 isoform numbering) was observed specifically in the brain. Neuron-specific phosphorylation of APP at T668 is...

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Main Authors: Chang, Keun-A, Kim, Hye-Sun, Ha, Tae-Young, Ha, Ji-Won, Shin, Ki Young, Jeong, Yun Ha, Lee, Jean-Pyo, Park, Cheol-Hyoung, Kim, Seonghan, Baik, Tae-Kyoung, Suh, Yoo-Hun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489099/
https://ncbi.nlm.nih.gov/pubmed/16705182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02393-05
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