Phosphorylation of Amyloid Precursor Protein (APP) at Thr668 Regulates the Nuclear Translocation of the APP Intracellular Domain and Induces Neurodegeneration

Amyloid precursor protein (APP) has eight potential phosphorylation sites in its cytoplasmic domain. Recently, it has demonstrated that the constitutive phosphorylation of APP at T668 (APP695 isoform numbering) was observed specifically in the brain. Neuron-specific phosphorylation of APP at T668 is...

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Autores principales: Chang, Keun-A, Kim, Hye-Sun, Ha, Tae-Young, Ha, Ji-Won, Shin, Ki Young, Jeong, Yun Ha, Lee, Jean-Pyo, Park, Cheol-Hyoung, Kim, Seonghan, Baik, Tae-Kyoung, Suh, Yoo-Hun
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489099/
https://ncbi.nlm.nih.gov/pubmed/16705182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02393-05
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