c-Jun N-terminal Kinase (JNK) induces phosphorylation of amyloid precursor protein (APP) at Thr668, in okadaic acid-induced neurodegeneration

Several lines of evidence have revealed that phosphorylation of amyloid precursor protein (APP) at Thr668 is involved in the pathogenesis of Alzheimer’s disease (AD). Okadaic acid (OA), a protein phosphatase-2A inhibitor, has been used in AD research models to increase tau phosphorylation and induce...

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Detalhes bibliográficos
Publicado no:BMB Rep
Main Authors: Ahn, Ji-Hwan, So, Sang-Pil, Kim, Na-Young, Kim, Hyun-Ju, Yoon, Seung-Yong, Kim, Dong-Hou
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Biochemistry and Molecular Biology 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032005/
https://ncbi.nlm.nih.gov/pubmed/26839154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2016.49.7.246
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