Pharmacogenomic polygenic response score predicts ischaemic events and cardiovascular mortality in clopidogrel-treated patients

AIMS : Clopidogrel is prescribed for the prevention of atherothrombotic events. While investigations have identified genetic determinants of inter-individual variability in on-treatment platelet inhibition (e.g. CYP2C19*2), evidence that these variants have clinical utility to predict major adverse...

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發表在:Eur Heart J Cardiovasc Pharmacother
Main Authors: Lewis, Joshua P, Backman, Joshua D, Reny, Jean-Luc, Bergmeijer, Thomas O, Mitchell, Braxton D, Ritchie, Marylyn D, Déry, Jean-Pierre, Pakyz, Ruth E, Gong, Li, Ryan, Kathleen, Kim, Eun-Young, Aradi, Daniel, Fernandez-Cadenas, Israel, Lee, Ming Ta Michael, Whaley, Ryan M, Montaner, Joan, Gensini, Gian Franco, Cleator, John H, Chang, Kiyuk, Holmvang, Lene, Hochholzer, Willibald, Roden, Dan M, Winter, Stefan, Altman, Russ B, Alexopoulos, Dimitrios, Kim, Ho-Sook, Gawaz, Meinrad, Bliden, Kevin P, Valgimigli, Marco, Marcucci, Rossella, Campo, Gianluca, Schaeffeler, Elke, Dridi, Nadia P, Wen, Ming-Shien, Shin, Jae Gook, Fontana, Pierre, Giusti, Betti, Geisler, Tobias, Kubo, Michiaki, Trenk, Dietmar, Siller-Matula, Jolanta M, ten Berg, Jurriën M, Gurbel, Paul A, Schwab, Matthias, Klein, Teri E, Shuldiner, Alan R
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363022/
https://ncbi.nlm.nih.gov/pubmed/31504375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ehjcvp/pvz045
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