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Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical endpoints - Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)

RATIONALE: The P2Y(12) receptor inhibitor clopidogrel is widely used in patients with acute coronary syndrome, percutaneous coronary intervention or ischemic stroke. Platelet inhibition by clopidogrel shows wide inter-patient variability and high on-treatment platelet reactivity is a risk factor for...

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書目詳細資料
發表在:	Am Heart J
Main Authors:	Bergmeijer, Thomas O., Reny, Jean-Luc, Pakyz, Ruth E., Gong, Li, Lewis, Joshua P., Kim, Eun-Young, Aradi, Daniel, Fernandez-Cadenas, Israel, Horenstein, Richard B., Lee, Ming Ta Michael, Whaley, Ryan M., Montaner, Joan, Gensini, Gian Franco, Cleator, John H., Chang, Kiyuk, Holmvang, Lene, Hochholzer, Willibald, Roden, Dan M., Winter, Stefan, Altman, Russ B., Alexopoulos, Dimitrios, Kim, Ho-Sook, Déry, Jean-Pierre, Gawaz, Meinrad, Bliden, Kevin, Valgimigli, Marco, Marcucci, Rossella, Campo, Gianluca, Schaeffeler, Elke, Dridi, Nadia P., Wen, Ming-Shien, Shin, Jae Gook, Simon, Tabassome, Fontana, Pierre, Giusti, Betti, Geisler, Tobias, Kubo, Michiaki, Trenk, Dietmar, Siller-Matula, Jolanta M., ten Berg, Jurriën M., Gurbel, Paul A., Hulot, Jean-Sebastien, Mitchell, Braxton D., Schwab, Matthias, Ritchie, Marylyn DeRiggi, Klein, Teri E., Shuldiner, Alan R.
格式:	Artigo
語言:	Inglês
出版:	2017
主題:	Article
在線閱讀:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5903579/ https://ncbi.nlm.nih.gov/pubmed/29653637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ahj.2017.12.010
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Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical endpoints - Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)

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