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NAADP‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca(2+) nanodomains, calcineurin and dynamin
Macrophages clear pathogens by phagocytosis and lysosomes that fuse with phagosomes are traditionally regarded as to a source of membranes and luminal degradative enzymes. Here, we reveal that endo‐lysosomes act as platforms for a new phagocytic signalling pathway in which FcγR activation recruits t...
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| 出版年: | EMBO J |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7360967/ https://ncbi.nlm.nih.gov/pubmed/32510172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019104058 |
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