Expression of Ca(2+)-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

The second messenger NAADP triggers Ca(2+) release from endo-lysosomes. Although two-pore channels (TPCs) have been proposed to be regulated by NAADP, recent studies have challenged this. By generating the first mouse line with demonstrable absence of both Tpcn1 and Tpcn2 expression (Tpcn1/2(−/−)),...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Ruas, Margarida, Davis, Lianne C, Chen, Cheng-Chang, Morgan, Anthony J, Chuang, Kai-Ting, Walseth, Timothy F, Grimm, Christian, Garnham, Clive, Powell, Trevor, Platt, Nick, Platt, Frances M, Biel, Martin, Wahl-Schott, Christian, Parrington, John, Galione, Antony
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Ltd 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516428/
https://ncbi.nlm.nih.gov/pubmed/25872774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490009
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