Expression of Ca(2+)-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

The second messenger NAADP triggers Ca(2+) release from endo-lysosomes. Although two-pore channels (TPCs) have been proposed to be regulated by NAADP, recent studies have challenged this. By generating the first mouse line with demonstrable absence of both Tpcn1 and Tpcn2 expression (Tpcn1/2(−/−)),...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Ruas, Margarida, Davis, Lianne C, Chen, Cheng-Chang, Morgan, Anthony J, Chuang, Kai-Ting, Walseth, Timothy F, Grimm, Christian, Garnham, Clive, Powell, Trevor, Platt, Nick, Platt, Frances M, Biel, Martin, Wahl-Schott, Christian, Parrington, John, Galione, Antony
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516428/
https://ncbi.nlm.nih.gov/pubmed/25872774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490009
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