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Expression of Ca(2+)-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells
The second messenger NAADP triggers Ca(2+) release from endo-lysosomes. Although two-pore channels (TPCs) have been proposed to be regulated by NAADP, recent studies have challenged this. By generating the first mouse line with demonstrable absence of both Tpcn1 and Tpcn2 expression (Tpcn1/2(−/−)),...
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| 出版年: | EMBO J |
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| 主要な著者: | , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley & Sons, Ltd
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4516428/ https://ncbi.nlm.nih.gov/pubmed/25872774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490009 |
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