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NAADP‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca(2+) nanodomains, calcineurin and dynamin
Macrophages clear pathogens by phagocytosis and lysosomes that fuse with phagosomes are traditionally regarded as to a source of membranes and luminal degradative enzymes. Here, we reveal that endo‐lysosomes act as platforms for a new phagocytic signalling pathway in which FcγR activation recruits t...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7360967/ https://ncbi.nlm.nih.gov/pubmed/32510172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019104058 |
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