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The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: Role for the two-pore channels

Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca(2+) that is tapped by the Ca(2+)-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca(2+) release from this acidic Ca(2+) store proceeds through activation of the newly...

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Main Authors: Patel, Sandip, Ramakrishnan, Latha, Rahman, Taufiq, Hamdoun, Amro, Marchant, Jonathan S., Taylor, Colin W., Brailoiu, Eugen
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160778/
https://ncbi.nlm.nih.gov/pubmed/21529939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2011.03.011
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