An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca(2+) Signals

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous messenger proposed to stimulate Ca(2+) release from acidic organelles via two-pore channels (TPCs). It has been difficult to resolve this trigger event from its amplification via endoplasmic reticulum Ca(2+) stores, fuelling specu...

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Bibliographic Details
Main Authors: Brailoiu, Eugen, Rahman, Taufiq, Churamani, Dev, Prole, David L., Brailoiu, G. Cristina, Hooper, Robert, Taylor, Colin W., Patel, Sandip
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992283/
https://ncbi.nlm.nih.gov/pubmed/20880839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.162073
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